CONSIDERATIONS TO KNOW ABOUT NR1-SITE

Working with this tactic, Kalbaugh et al. assigned affinity and efficacy roles to positions during the LBDs from the NR1 and NR2A NMDAR subunits. In situ mutation of residues in direct contact with bound ligand impacted both equally efficacy and affinity, although positions that stabilize the shut cleft conformation without having a direct ligand i